From St. Louis : Travel south on I-55 to Exit 58/Hwy. 80/Matthews/East Prairie. After exiting, turn east toward East Prairie and follow Hwy. 80 through East Prairie. Turn right/south onto Hwy. 77 and continue approximately eight miles to County Road 502. Turn right/west onto the gravel road; the historic site is one mile ahead on the left.

From Jefferson City : Travel east on U.S. Hwy. 54 to Kingdom City. Take I-70 east to Exit 210A/U.S. Hwy. 41/61/Kirkwood/Forest Park. Take U.S. Hwy. 40 east to Exit 25/I-270/Chicago/Memphis; merge onto I-270 south and continue for about 11 miles. Take Exit 1B-A/I-55/St. Louis/Memphis and head south on I-55. At Exit 58/Hwy. 80/Matthews/East Prairie, turn east toward East Prairie and follow Hwy. 80 through East Prairie. Turn right/south onto Hwy. 77 and continue approximately eight miles to County Road 502. Turn right/west onto the gravel road; the historic site is one mile ahead on the left.

From Springfield, Mo. : Travel east on U.S. Hwy. 60 to the Sikeston area. Take Exit 1A/I-55/Memphis and head south for about seven miles. Take Exit 58/Hwy. 80/Matthews/East Prairie and turn east toward East Prairie. Follow Hwy. 80 through East Prairie; turn right/south onto Hwy. 77 and travel approximately eight miles. Turn right/west onto County Road 502 (gravel road); the historic site is one mile ahead on the left.